New Orleans Saints vs Carolina Panthers Odds, Picks & Predictions for Week 1

The 2024 NFL season ends in the Caesars Superdome for Super Bowl LIX. The stadium starts the season by hosting the Week 1 matchup between the New Orleans Saints (9-8, 6-10-1 ATS last season) and NFL South division rival the Carolina Panthers (2-15, 5-11-1 ATS) on Sunday afternoon (1 pm ET).

New Orleans tried to move on from the Drew Brees Era last season and paid big money for quarterback Derek Carr to take over under center. Results were mixed. Carr was beat up behind a porous offensive line, but the Saints did play well down the stretch and were in the playoff hunt until the end.

New Orleans is listed as four-point favorites in most sportsbooks in the Week 1 NFL odds, while the game total ranges from 41.5 to 42.

Here’s my best picks for Saints vs Panthers for…